Rechercher dans ce blog

Wednesday, September 30, 2020

The First Person to Be Cured of HIV Has Passed Away From Cancer - ScienceAlert

The first person to be cured of HIV, Timothy Ray Brown - known as the "Berlin Patient" - has died from cancer, the International AIDS Society (IAS) announced Wednesday. 

Brown made medical history and became a symbol of hope for the tens of millions of people living with the virus that causes AIDS when he was cured more than a decade ago.

He had been living with a recurrence of leukaemia for several months and received hospice care at his home in Palm Springs, California. 

"On behalf of all its members... the IAS sends its condolences to Timothy's partner, Tim, and his family and friends," said IAS President Adeeba Kamarulzaman. 

"We owe Timothy and his doctor, Gero Hutter, a great deal of gratitude for opening the door for scientists to explore the concept that a cure for HIV is possible."

Brown was diagnosed with HIV while he was studying in Berlin in 1995. A decade later, he was diagnosed with leukaemia, a cancer that affects the blood and bone marrow.

To treat his leukaemia, his doctor at the Free University of Berlin used a stem cell transplant from a donor who had a rare genetic mutation that gave him natural resistance to HIV, hoping it may wipe out both diseases.

It took two painful and dangerous procedures, but it was a success: in 2008 Brown was declared free of the two ailments, and was initially dubbed "the Berlin Patient" at a medical conference to preserve his anonymity.

Two years later, he decided to break his silence and went on to become a public figure, giving speeches and interviews and starting his own foundation.

"I am living proof that there could be a cure for AIDS," he told AFP in 2012. "It's very wonderful, being cured of HIV."

'Champion'

Ten years after Brown was cured, a second HIV patient - dubbed "the London Patient" - was revealed to be in remission 19 months after undergoing a similar procedure. 

The patient, Adam Castillejo, is currently HIV-free. In August a California woman was reported to have no traces of HIV despite not using anti-retroviral treatment. 

It is thought she may be the first person to be cured of HIV without undergoing the risky bone marrow treatment. 

Sharon Lewin, president-elect of the IAS and director of the Doherty Institute in Melbourne, Australia, praised Brown as a "champion and advocate" of a cure for HIV.

"It is the hope of the scientific community that one day we can honour his legacy with a safe, cost-effective and widely accessible strategy to achieve HIV remission and cures using gene editing or techniques that boost immune control," she said.

© Agence France-Presse

Let's block ads! (Why?)



Health - Latest - Google News
October 01, 2020 at 09:46AM
https://ift.tt/30nkbhq

The First Person to Be Cured of HIV Has Passed Away From Cancer - ScienceAlert
Health - Latest - Google News
https://ift.tt/2zrj9Ud

As virus rates decrease, evacuations pose a risk - Sonoma West

The county gave an update on its COVID-19 numbers Wednesday night, bringing back into focus the pandemic that’s in some ways taken a backseat while local residents grapple with its second fire of the year. While Sonoma County’s virus case statistics have been steadily improving, the evacuation of a sizable number of Sonoma County residents leaves some unknowns for how case rates may fluctuate in the weeks ahead.

As of Tuesday night, the county has 7,528 total virus cases, with 1,253 cases active and 6,153 recovered. There have been 122 deaths.

The county remains in the state’s purple tier, making it the only county in the Bay Area to still be marked as having “widespread” transmission of the virus. During the state’s weekly Tuesday evaluation of where counties in California stand when it comes to virus metrics, the only other Bay Area county in the purple tier, Contra Costa, was bumped to the red tier, denoting “substantial” virus spread. If a county stays on a lower tier for two weeks (if Sonoma County were to move to the red tier, for example), new business sectors are allowed to open and some additional health order restrictions may be loosened.

The tier designation is based on two metrics — new positive cases per day per 100,000 residents and test positivity rate.

As of Sept. 30, the daily case rate for Sonoma County is 7.8 new cases per day per 100,000 people, which is slightly above the lower than 7 cases per 100,000 that would allow the county to move into the red tier designation. The county has a 4% test positivity rate, which is below the percentage required to move down to the state’s red tier. Counties must meet both metrics in order to be reclassified.

However, as county case numbers are reaching levels that point toward Sonoma County being classified as only having “substantial” virus spread, tens of thousands of people residing in the county have had to evacuate their homes due to the Glass Fire.

“As we face yet another wildfire, this time with tens of thousands of evacuees, it’s important to remember the basics when evacuating during COVID-19,” Sonoma County Health Officer Dr. Sundari Mase said. “Though it becomes more difficult to do, we strongly urge you to remember the fundamentals of COVID-19 safety and all of the mitigation measures we’ve been talking about. Wear a face covering whenever possible. Keep your distance from others, at least six feet away from non-household members if at all possible. Wash your hands often, clean surfaces and follow all of the general hygiene measures we’ve been talking about all along.”

For those who may be evacuated to someone else’s house, Mase urged people to remember to wear a face covering in shared spaces, disinfect surfaces after use, maintain distance and, if possible, have the person stay in a separate room and use a separate bathroom.

“We’ve had even more evacuations in this last week and I think we need to be really careful about ensuring that anybody who evacuated and who feels ill in any way should get tested, go see your doctor. People who worry that they may have been exposed because they evacuated should make an appointment with OptumServe and get tested, and have a heightened awareness for the possibility of an increase in cases as a result of these evacuations,” Mase said.

According to Mase, everybody who comes through the county’s evacuation points is screened for virus symptoms and, if they show signs of possibly having the virus, a rapid-response test is administered.

“We’re thinking that we have done a fairly good job of screening out those people who could actually be COVID cases in the shelters,” she said.

While virus test processing has slowed down over the past few days due to county staff being displaced by the fire, Mase said that the county is now back to operating at 100%.

“We’re waiting to hear from the state whether, as a result of our decreased capacity to test and run the specifics, whether they may change the way they do the assessment for Sonoma County,” Mase said when asked if the temporary dip in health department staffing will result in Sonoma County not being reevaluated for a tier-change next week.

Let's block ads! (Why?)



"virus" - Google News
October 01, 2020 at 12:48PM
https://ift.tt/2SbsJU4

As virus rates decrease, evacuations pose a risk - Sonoma West
"virus" - Google News
https://ift.tt/2OagXru

Neanderthal genes may be to blame in some severe coronavirus cases - CNN

A team of experts on Neanderthal genetics examined a strand of DNA that has been associated with some of the more serious cases of Covid-19 and compared it to sequences known to have been passed down to living Europeans and Asians from Neanderthal ancestors.
The DNA strand is found on chromosome 3, and a team of researchers in Europe has linked certain variations in this sequence with the risk of being more severely ill with Covid-19.
"Here, we show that the risk is conferred by a genomic segment ... that is inherited from Neanderthals and is carried by about 50% of people in South Asia and about 16% of people in Europe today," Svante Paabo and Hugo Zeberg of the Max Planck Institute for Evolutionary Anthropology wrote, in a paper accepted for publication in the journal Nature.
"It turns out that this gene variant was inherited by modern humans from the Neanderthals when they interbred some 60,000 years ago," Zeberg said in a statement.
"Today, the people who inherited this gene variant are three times more likely to need artificial ventilation if they are infected by the novel coronavirus Sars-CoV-2."
Paabo and Zeberg found similar variations in the DNA from a 50,000-year-old Neanderthal skeleton found in Croatia and a few of them in skeletons found in Siberia, as well.
Studies have shown that modern humans interbred with Neanderthals and a related species, known as the Denisovans, tens of thousands of years ago. Studies estimate that about 2% of DNA in people of European and Asian descent can be traced back to Neanderthals.
"It is currently not known what feature in the Neanderthal-derived region confers risk for severe Covid-19 and if the effects of any such feature is specific to SARS-CoV-2, to other coronaviruses or to other pathogens," the researchers wrote.
"There really isn't anything medically or biologically special about the fact that this variant arose in Neanderthals," Dr. Jeffrey Barret, a geneticist at Britain's Sanger Institute who was not involved in the study, told CNN.
"Humans have a great deal of genetic diversity, some of which arose in our pre-human ancestors, some in Neanderthals, some during the time when all ancient humans lived in Africa, and some more recently."
Barret said this particular stretch of DNA explains only a small percentage of the differences in illness severity among coronavirus patients.
"However, with respect to the current pandemic, it is clear that gene flow from Neanderthals has tragic consequences," Paabo and Zeberg concluded in their study.

Let's block ads! (Why?)



COVID-19 - Latest - Google News
October 01, 2020 at 07:53AM
https://ift.tt/2HGddgR

Neanderthal genes may be to blame in some severe coronavirus cases - CNN
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

Timothy Ray Brown, first man cured of HIV, has died of cancer - CBS News

Timothy Ray Brown, who made history as the first person known to be cured of HIV infection, has died from cancer at 54, The Associated Press reports. Brown died on Tuesday, his partner Tim Hoeffgen, announced in a social media post.

Brown was known as the "Berlin patient" because he had been living in the German city with both HIV and leukemia when he received the treatment that apparently cured him.

While receiving chemotherapy for his cancer in 2007 and 2008, Brown became so sick he was put into a coma. Doctors weren't even sure he would survive. So, Brown underwent stem cell transplants from a donor who was immune to HIV, in hopes of curing his cancer. Doctors declared Brown "cured" in 2008, not long after his blood stem cell transplant.

In 2011, reporter Hank Plante with CBS San Francisco reported on the progress of Brown's treatment. Brown said being the first man to be cured of HIV made him very happy.

Dr. Jay Levy, a co-discoverer of the HIV virus, explained the treatment that lead to Brown's cure. "If you're able to take the white cells from someone and manipulate them so they're no longer infectable by HIV, and those white cells become the whole immune system of that individual, you've got essentially what we call a functional cure," Dr. Levy said, Plante reported.

Brown said in 2011 he had stopped taking his HIV medication the day he received the transplant and had not taken any since. 

The cause of Brown's death was a return of the cancer that originally prompted the unusual treatment that cured him of HIV, the AP reported.

Dr. Gero Huetter, the Berlin physician who led Brown's historic treatment, called his death, "a very sad situation," because he still seemed free of HIV.

Huetter, who is now medical director of a stem cell company in Dresden, Germany, said "Timothy symbolized that it is possible, under special circumstances," to rid a patient of the virus, according to the AP. 

In a statement on Brown's death Wednesday, Adeeba Kamarulzaman, president of the International AIDS Society (IAS), said: "We owe Timothy and his doctor, Gero HĂŒtter, a great deal of gratitude for opening the door for scientists to explore the concept that a cure for HIV is possible."

While the transplant treatment also "cured" another man known as the London patient, the exact method is not one that's going to be widely available to the nearly 38 million people worldwide living with the virus, experts say, according to HealthDay. 

The Berlin and London patients benefited from a combination of medical and genetic chance, the experts explained. While the method of treatment was effective, both could have easily been killed by it.

Last year, researchers eliminated HIV from mice using gene editing, marking the first time it was eradicated from the genomes of living animals, according to the study's authors. Researchers used both CRISPR-Cas9, a gene editing system and a drug regimen called long-acting slow-effective release (LASER) ART. The mice were treated with LASER ART and then with CRISPR-Cas9, which eliminated HIV DNA from about one-third of the mice. Research, however, might not have the same results in humans, HealthDay reported.

Let's block ads! (Why?)



Health - Latest - Google News
October 01, 2020 at 02:07AM
https://ift.tt/33gQKPM

Timothy Ray Brown, first man cured of HIV, has died of cancer - CBS News
Health - Latest - Google News
https://ift.tt/2zrj9Ud

COVID-19 clusters in NYC growing at an alarming rate - New York Post

The outer borough COVID spike is growing.

City Hall revealed late Wednesday that the major southern Brooklyn coronavirus outbreak cluster now spans from Brighton Beach all the way to eastern Crown Heights — as officials added a slew of new neighborhoods to the list of those witnessing concerning spikes in COVID test rates.

Clusters in Southern Brooklyn, Williamsburg, Central Queens and Far Rockaway neighborhoods recorded positive coronavirus infection rates between 3 and almost 7 percent based on a two week rolling average that’s continuing to drive up the citywide infection rate past 3 percent.

Five zip codes in Brooklyn and Queens already on the city’s COVID hotspot watchlist — now grown to 10 neighborhoods with infection rates higher than 3 percent — tracked spikes over a 24-hour period.
Borough Park’s positive infection rate rests at 6.51 percent, up .0.28 percent compared to Tuesday’s data, Bensonhurst/Mapleton saw a 0.26 percent increase over the same time period, bringing the neighborhood to a 6.31 percent average infection rate.

Gerritsen Beach/Homecrest/Sheepshead Bay’s infection rate is recorded at 4.13 percent, up 0.08 percent, and Kew Gardens Hills/Pomonok is at 3.68 percent — also an increase of 0.08 compared to the previous day.

A new neighborhood — Fresh Meadows/Hillcrest — was added to Gotham’s hotspot list, tracking a 3.08 percent infection rate — a 0.22 increase from the day prior.

Meanwhile, Edgemere/Far Rockaway, Gravesend/Homecrest, Midwood, Flatlands, Kew Gardens saw slight declines in their positive infection rates, although they alarmingly remained above the city’s 3 percent threshold.

These ten areas make up over 27.5 percent of Gotham’s new virus cases over the past two weeks, accounting for 7.5 percent of the city’s overall population.

City health officials also added a new category of seven communities recording virus upticks hovering between an average of 2 to 3 percent — which include Williamsburg, Crown Heights East, Bedford-Stuyvesant West,/Clinton Hill/Fort Greene and Hillcrest/Jamaica Estates/Jamaica Hills.

Viral videos and firsthand reporting by The Post give witness to maskless gatherings and large crowds, despite continuous pleas by Mayor Bill de Blasio and Gov. Andrew Cuomo for New Yorkers to practice social distancing and don face coverings.

De Blasio has also threatened to rollback progress in certain areas if noncompliance persists, and even close public schools should positive infection rates persist above 3 percent on a seven day rolling average.

The clusters — several home to members of the Orthodox Jewish community — have drawn ire from Gov. Andrew Cuomo — who said he spoke with Jewish leaders Wednesday.

“I spoke to the leaders of the Orthodox community this morning and we had a good conversation,” Cuomo told reporters during a late-morning conference call.

“We’re nowhere near herd immunity,” he seethed, listing eight hotspots in Brooklyn and Queens have also landed themselves on a statewide list tracking New York’s top ten zip codes seeing COVID-19 spikes.

Gov. Andrew Cuomo
Gov. Andrew Cuomo Robert MIller

Cuomo slammed local governments — without naming Mayor de Blasio — but he did complain that compliance enforcement by the state police were not enough, and he may need local police departments — including the NYPD — to lend officers for a special COVID compliance task force.

“The local governments must do compliance,” he insisted.

“It is a state law and the localities must enforce it…they have to enforce the state law and they’re not doing it with enough diligence. Period.”

“They’ve made it worse, not better,” he criticized local officials.

Cuomo has also questioned members of the NYPD’s alleged refusal to wear masks, asking Tuesday:

“What kind of message does that send?” during a phone call with reporters.

When questioned on the topic Wednesday, De Blasio told reporters officers who flout the rule should “face penalties” he has brought up the issue with NYPD Commissioner Dermot Shea.

“Our officers should be held to the same standard as all citizens, all public standards,” he said during his daily televised press conference.

The state Health Department recorded a 1.2 percent positive infection rate over the last 24-hour period for New York City.

The statewide average stands at 1.02 percent following 97,960 tests performed and 1,000 recorded as positive.

There were nine deaths in the Empire State, as well as 605 individuals hospitalized, 144 patients admitted to the ICU and of that group, 67 were intubated.

Additional reporting by Nolan Hicks

Let's block ads! (Why?)



COVID-19 - Latest - Google News
October 01, 2020 at 08:00AM
https://ift.tt/3igASkQ

COVID-19 clusters in NYC growing at an alarming rate - New York Post
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

In blow to Trump, Moderna’s Covid-19 vaccine won’t be ready by US election - South China Morning Post

[unable to retrieve full-text content]

  1. In blow to Trump, Moderna’s Covid-19 vaccine won’t be ready by US election  South China Morning Post
  2. Will Pfizer's Vaccine Be Ready in October? Here's Why That's Unlikely.  The New York Times
  3. Could cats hold the key to a COVID-19 vaccine?  WJW FOX 8 News Cleveland
  4. Moderna chief says its vaccine won't be ready before US election  Financial Times
  5. GlaxoSmithKline CEO Walmsley: COVID-19 is pharma's chance for redemption  FiercePharma
  6. View Full Coverage on Google News


Health - Latest - Google News
October 01, 2020 at 06:46AM
https://ift.tt/3cNKDFL

In blow to Trump, Moderna’s Covid-19 vaccine won’t be ready by US election - South China Morning Post
Health - Latest - Google News
https://ift.tt/2zrj9Ud

China contained Covid-19. Now, hundreds of millions of people there are about to go on vacation at the same time - CNN

Hong Kong (CNN) — China is on the move again. As October 1 arrives, hundreds of millions of people are expected to pack highways, trains and planes for the National Day holiday, one of the busiest times for travel in the world's most populous country.

The eight-day break is China's first major holiday since it emerged from the coronavirus outbreak. While life has largely returned to normal in recent months, the upcoming "Golden Week" holiday will be an ambitious test of China's success in taming the virus -- and a much-awaited boost to its economic recovery.
Last year, a total of 782 million domestic trips were made during the holiday, generating nearly 650 billion yuan ($95 billion) of tourism revenue, according to the Ministry of Culture and Tourism.
Tourists crowd the Leshan Giant Buddha in China's Sichuan province during the National Day holiday in 2019.

Tourists crowd the Leshan Giant Buddha in China's Sichuan province during the National Day holiday in 2019.

Liu Zhongjun/China News Service/VCG/Getty Images

The ministry predicts 550 million domestic trips to be made this year, while Ctrip, China's largest online travel agency, estimates the number to be over 600 million -- both above 70% of last year's level.
The scale of mass movement in such a short period of time is unthinkable in many parts of the world, where governments are still struggling to control soaring infections. In the United States, the number of coronavirus cases topped 7 million over the weekend. Much of Europe is now in the grip of a second wave of infections; even countries largely spared by the first wave, such as Greece and Croatia, have seen cases surging as tourists took summer vacations following the reopening of Europe's internal borders in June.

But for now, the virus is much less of a concern for Chinese holidaymakers, given China's close to zero local transmission and some of the world's strictest border control measures.

Chen Qianmei, a 29-year-old from the southern city of Guangzhou, flew to Shanghai on Tuesday for her vacation. She said she wasn't worried about the virus, although she still took precautions.

"I think China has (the virus) under pretty good control," she said. "I'm wearing masks and bringing alcohol wipes with me to clean my hands, especially before eating -- although in Shanghai, few people wear masks now."

Chinese security personnel keep watch on the crowds on a popular pedestrian shopping street during the 'Golden Week' holiday in Shanghai in 2017.

Chinese security personnel keep watch on the crowds on a popular pedestrian shopping street during the 'Golden Week' holiday in Shanghai in 2017.

AFP Contributor/AFP/AFP via Getty Images

Show of confidence

The coronavirus, first detected in the central Chinese city of Wuhan last December before spreading across the globe, has been largely contained in China since March. In the following months, small-scale outbreaks have occasionally flared -- from the country's northeast to the capital Beijing and the far western region of Xinjiang, but all were swiftly contained through stringent lockdown measures and mass testing programs.

China has not reported any locally transmitted symptomatic case since mid-August, and is rigorously screening overseas arrivals and workers at risk of exposure to the virus. Last week, it detected its first local asymptomatic infections in over a month, after two port workers unloading frozen imported seafood in Qingdao tested positive for the virus in routine screening.

Two residents walk in an empty park during the Lunar New Year holiday on January 27 in Wuhan, China.

Two residents walk in an empty park during the Lunar New Year holiday on January 27 in Wuhan, China.

Stringer/Getty Images

The sense of control is in stark contrast to the anxiety and foreboding that had overshadowed China's last major travel period -- the Lunar New Year holiday in late January. Back then, the coronavirus outbreak was sweeping through Wuhan after local authorities initially silenced healthcare workers trying to sound the alarm. Two days before Lunar New Year's Day, the Chinese government ordered an unprecedented lockdown on the city, but by then, the virus had already spread to other provinces and beyond the country, as hundreds of millions of Chinese people headed home for family reunions or took vacations overseas.

More than eight months on, China's restrictions on domestic movement have all been lifted. Officially, some cities still require passengers to produce a green health code on their smartphones at train stations and airports to show they're safe to travel, but implementation can be lax in practice.
In a sign of the government's confidence in keeping the virus under control, the Chinese Center for Disease Control and Prevention said last week that domestic travels can be arranged "as normal" for the upcoming holiday, given all cities in mainland China are marked as low risk for the coronavirus.

But the center still recommended travelers obey local epidemic control measures, wear masks on trains, flights and in crowded places, and keep 1-meter (3.2 feet) distance at tourist spots -- the last of which could be difficult if not impossible to observe, given the size of crowds that often inundate popular sites during Chinese holidays.

Last week, China's Culture and Tourism Ministry ordered tourist sites to restrict capacity to 75% during the Golden Week, up from a limit of 50% from previous months. To facilitate contact tracing, visitors are required to register online in advance.

Tourists wearing face masks line up outside the Yellow Crane Tower in Wuhan, China on September 3.

Tourists wearing face masks line up outside the Yellow Crane Tower in Wuhan, China on September 3.

HECTOR RETAMAL/AFP/AFP via Getty Images

Wu Zunyou, chief epidemiologist at the Chinese CDC, told state broadcaster CCTV earlier this month that there is no need to impose extra restrictions for domestic travel during the National Day holiday, because the coronavirus is no longer circulating in society.
"It is now impossible to contract the virus in social environments," he said. "Although we are still finding dozens of imported cases among travelers arriving in China on international flights, the imported cases are managed in a closed loop and won't spread to society, and therefore won't have much impact on domestic residents."

Domestic travel boost

Chinese authorities -- including the Chinese CDC and foreign ministry -- have urged Chinese citizens to avoid unnecessary overseas travel, citing the still-raging pandemic across the world.

The Golden Week holiday -- the longest in China along with the Lunar New Year holiday -- has traditionally seen middle-class Chinese travel abroad in large numbers. Last year, more than 7 million overseas trips were made during the holiday, with Japan and Thailand among the top destinations, government data showed.
Chinese tourists wait for their tour bus in the Ginza shopping district on October 02, 2019 in Tokyo, Japan.

Chinese tourists wait for their tour bus in the Ginza shopping district on October 02, 2019 in Tokyo, Japan.

Tomohiro Ohsumi/Getty Images AsiaPac/Getty Images

But this year, overseas trips will be practically impossible to make, given the various visa restrictions and quarantine requirements imposed around the world, as well as a lack of international flights. Upon their return to China, travelers must also face two weeks of strict quarantine -- with at least half of the time required to be spent in government-appointed hotels.

The only exception is Macau, which waived quarantine requirements in July for mainland travelers who obtained a negative test result for coronavirus within seven days. Last week, mainland China fully resumed tourist visas for the semi-autonomous region, just in time for the National Day holiday.

As Chinese holidaymakers turn to domestic destinations, local governments are competing to attract tourists. According to Ctrip, more than 20 provincial and municipal governments have issued travel vouchers, while some 1,500 tourist spots across China have offered free or discounted tickets.
China's railway operator, China State Railway Group, expected a total of 108 million train rides from September 28 to October 8. To cope with the increased demand, an additional 1,200 trains have been added to service, but some tickets along popular routes have been snapped up anyway.
Some flights have also sold out. Qunar, a Chinese online travel booking site, estimated more than 15 million domestic flight tickets would be sold for Golden Week, a 10% increase from 2019, partly due to a drop in the price of airfares.
And on Chinese highways, massive traffic jams are expected again this year. An average of 51 million highway trips per day are expected during the eight-day holiday, a 1% to 3% increase from last year, according to the Transport Ministry.
Tourists take a selfie at the the Yellow Crane Tower in Wuhan on September 3, 2020.

Tourists take a selfie at the the Yellow Crane Tower in Wuhan on September 3, 2020.

HECTOR RETAMAL/AFP/AFP via Getty Images

Wuhan, the original epicenter of the outbreak, has become a popular destination for Chinese tourists since its lockdown was lifted in April. Last month, Hubei province, of which Wuhan is the capital, announced that nearly 400 of its tourist attractions would be open for tourists for free until the end of the year. On a booking platform set up by the province since the announcement, more than 3.74 million tickets for tourist sites in Wuhan were booked in just over a month, according to the state-run Hubei Daily.
The Yellow Crane Tower, a famous landmark of Wuhan, topped the list of the most sought-after attractions for Golden Week, according to Ctrip.

Let's block ads! (Why?)



COVID-19 - Latest - Google News
October 01, 2020 at 07:41AM
https://ift.tt/30o8yXA

China contained Covid-19. Now, hundreds of millions of people there are about to go on vacation at the same time - CNN
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

Moderna’s Covid Vaccine Generated Strong Antibodies in the Elderly - Barron's

Protection of vulnerable groups will be a major factor when government regulators consider an emergency authorization of Moderna’s vaccine.

Maddie Meyer/Getty Images

Moderna announced that elderly people in the first trial of its Covid-19 vaccine generated high levels of antibodies against the coronavirus, on a par with younger test subjects and patients who have recovered from the illness.

In recent trading, Moderna stock (ticker: MRNA) was up 3.1%, at $72.73, while the Nasdaq Composite was up 1%.

Protection of vulnerable groups like the elderly will be a major factor when government regulators consider an emergency authorization of Moderna’s mRNA-1273 vaccine, upon completion of its Phase 3 study in the next month or two.

“Given the increased morbidity and mortality of Covid-19 in older and elderly adults, these data give us optimism in demonstrating mRNA-1273’s protection in this population,” said Moderna medical chief Tal Zaks in the Tuesday night announcement,

Moderna and a team of Pfizer (PFE) and BioNTech (BNTX) are both racing down the home stretch of enormous pivotal trials of their Covid vaccines. Pfizer has said it might have results by late October, but most observers are betting the two trials will reach their conclusions in November or December. Johnson & Johnson (JNJ) will be only a month or so behind with its Phase 3 trial results.

BioNTech and Pfizer use a similar technology to Moderna’s. BioNTech stock was up Wednesday morning, by 1.6%, at $67.95, while Pfizer was up 0.7%, at $36.42.

The U.S. Food and Drug Administration has told all vaccine developers that their studies must include participants from the populations hit hardest by Covid. Those groups are the elderly, disadvantaged minorities, and people with pre-existing medical conditions.

So Moderna was happy to announce a study that will appear in Wednesday’s New England Journal of Medicine, which analyzed the elderly participants in its vaccine’s Phase 1 trial.

The data show that the vaccine was well-tolerated in two age cohorts: those between ages 56 and 70, and those aged 71 and older. At the dose level that is being tested in Phase 3, the vaccine elicited levels of antibodies on a par with patients who have recovered from Covid. In the lab, the antibodies from Moderna’s elderly test subjects stopped the virus from infecting cells at an even higher rate than the antibodies of recovered patients.

Phase 3 studies will show whether vaccines from Moderna and its rivals actually prevent Covid infection—but the latest data from Moderna bodes well. The company notes that it already has a deal to sell 100 million doses to the U.S. government for $1.525 billion, with an option for another 400 million doses. It’s also getting $955 million in federal funding and can recoup its development costs.

So there is surely good revenue ahead for Moderna, if its vaccine works. Whether there will be enough to justify the company’s $26 billion market cap is something that investors must decide.

Write to Bill Alpert at william.alpert@barrons.com

Let's block ads! (Why?)



Health - Latest - Google News
September 30, 2020 at 09:19PM
https://ift.tt/30lTkSS

Moderna’s Covid Vaccine Generated Strong Antibodies in the Elderly - Barron's
Health - Latest - Google News
https://ift.tt/2zrj9Ud

91 Human West Nile Virus Cases Reported In California As Officials Encourage Risk Reduction - CBS Los Angeles

LOS ANGELES (CBSLA) — Spreading diseases such as malaria, West Nile and Zika, mosquitoes are among the deadliest animals in the world.

To date, California officials have reported a total of 91 West Nile virus cases in people statewide. Of those, L.A. County Public Health said it has identified 27 local cases.

West Nile virus, according to the Centers for Disease Control and Prevention, is the leading cause of mosquito-borne disease in the continental U.S.

Mosquito season is typically from March to late October or early November, and there are currently no vaccines to prevent or medications to treat the disease in people.

Most people infected with West Nile virus do not feel sick, but one in five people experience a fever and other symptoms, the CDC says.

About one out of 150 infected people develop serious and sometimes deadly reactions to the disease, according to health experts.

Lucas Meyers of Studio City says his brother-in-law contracted West Nile virus and has been hospitalized in the intensive care unit at Cedars Sinai for the past week.

“West Nile is I think far more powerful than anyone is discussing,” Meyers said. “He’s a wonderful, brilliant man full of energy and light and for a mosquito… to take so much of his life is devastating.”

Officials with the local vector control district that monitors mosquito counts in the area said the Native mosquito, the Culex Mosquito, can potentially transmit the virus and is most active at dusk and dawn.

The Greater L.A. Vector Control District said there has been an uptick in positive West Nile virus cases this season compared with the last two years, but this year’s trend is near average.

The increase this year could be due to dryer weather conditions since mosquitos reproduce in standing water and warm temperatures.

“Because we don’t have a lot of rain here in L.A. County to create these sources, we see that a lot of these sources are created by us watering our gardens or lawns you know, irrigating our own yards. We are creating sources in that sense.” Medina-Diaz said.

The Vector Control District has confirmed 237 samples of West Nile Virus in mosquitoes across Southern California so far this year, with the highest concentration in the San Fernando Valley.

The Vector control district is posting signs across the Valley warning residents that West Nile virus has been detected in the area.

You can reduce your risk of West Nile virus by using insect repellent and wearing long-sleeved shirts and long pants to prevent mosquito bites.

The vector control district also recommends getting rid of any standing water near your home.

She says people that are most vulnerable to West Nile virus complications are young children, the elderly, and those with underlying health conditions.

Let's block ads! (Why?)



"virus" - Google News
October 01, 2020 at 09:04AM
https://ift.tt/2Sg8Ivv

91 Human West Nile Virus Cases Reported In California As Officials Encourage Risk Reduction - CBS Los Angeles
"virus" - Google News
https://ift.tt/2OagXru

Study Finds ‘Single Largest Driver’ of Coronavirus Misinformation: Trump - The New York Times

WASHINGTON — Of the flood of misinformation, conspiracy theories and falsehoods seeding the internet on the coronavirus, one common thread stands out: President Trump.

That is the conclusion of researchers at Cornell University who analyzed 38 million articles about the pandemic in English-language media around the world. Mentions of Mr. Trump made up nearly 38 percent of the overall “misinformation conversation,” making the president the largest driver of the “infodemic” — falsehoods involving the pandemic.

The study, to be released Thursday, is the first comprehensive examination of coronavirus misinformation in traditional and online media.

“The biggest surprise was that the president of the United States was the single largest driver of misinformation around Covid,” said Sarah Evanega, the director of the Cornell Alliance for Science and the study’s lead author. “That’s concerning in that there are real-world dire health implications.”

The study identified 11 topics of misinformation, including various conspiracy theories, like one that emerged in January suggesting the pandemic was manufactured by Democrats to coincide with Mr. Trump’s impeachment trial, and another that purported to trace the initial outbreak in Wuhan, China, to people who ate bat soup.

But by far the most prevalent topic of misinformation topic was “miracle cures,” including Mr. Trump’s promotion of anti-malarial drugs and disinfectants as potential treatments for Covid-19, the disease caused by the coronavirus. That accounted for more misinformation than the other 10 topics combined, the researchers reported.

They found that of the more than 38 million articles published from Jan. 1 to May 26, more than 1.1 million — or slightly less than 3 percent — contained misinformation. They sought to identify and categorize falsehoods, and also tracked trends in reporting, including rises in coverage.

For example, on April 24, a day after Mr. Trump floated — and was ridiculed for — the idea that disinfectants and ultraviolet light might treat Covid-19, there were more than 30,000 articles in the “miracle cures” category, up from fewer than 10,000 only days earlier. Mr. Trump drove those increases, the study found.

To those who have been watching Mr. Trump’s statements, the idea that he is responsible for spreading or amplifying misinformation might not come as a huge shock. The president has also been feeding disinformation campaigns around the presidential election and mail-in voting that Russian actors have amplified — and his own government has tried to stop.

But in interviews, the Cornell researchers said they expected to find more mentions of conspiracy theories, and not so many articles involving Mr. Trump.

Public health experts know that clear, concise and accurate information is the foundation of an effective response to an outbreak of infectious disease. Misinformation around the pandemic is “one of the major reasons” the United States is not doing as well as other countries in fighting the pandemic, said Dr. Joshua Sharfstein, a vice dean at the Johns Hopkins Bloomberg School of Public Health and a former principal deputy commissioner at the Food and Drug Administration.

“There is a science of rumors. It’s when there is uncertainty and fear,” said Dr. Sharfstein, who teaches on public health crisis communications. In the absence of treatments or vaccines, he said, honest and consistent messaging is essential.

“This is what we need to save lives,” he said. “If it’s not done well, you get far more infections and deaths.”

The Cornell Alliance for Science, which spearheaded the study, is a nonprofit devoted to using science to enhance food security and improve environmental sustainability. One of its aims is to promote science-based decision-making. Dr. Evanega and a Cornell colleague, Mark Lynas, partnered with media researchers at Cision, a company that performs media analysis, to conduct the study. Dr. Evanega said the study was being peer reviewed by an academic journal, but the process was lengthy and the authors withdrew it because they felt they had compelling public health information to share.

The researchers sought to identify all mentions of misinformation in “traditional media” — including in The New York Times and other major news outlets. They included fact-checking articles that corrected misinformation in their total tally. But fact-checking articles accounted for only 16.4 percent of those that included misinformation, “suggesting that the majority of Covid misinformation is conveyed by the media without question or correction,” the authors wrote.

The study found that conspiracy theories, when lumped together, accounted for 46 percent of the misinformation mentions. Among those theories was one that emerged in early April suggesting that Dr. Anthony S. Fauci, the director of the National Institute of Allergy and Infectious Diseases and a respected voice on the pandemic, was exaggerating deaths or was a beneficiary of pharmaceutical company efforts to find treatments and vaccines. To look for such stories, they examined social media hashtags, including #FireFauci and #FauciFraud.

The researchers identified more than 11,000 misinformation articles involving Dr. Fauci, as compared with more than 295,000 involving miracle cures. There were more than 40,000 articles that mentioned the purported Democratic hoax, and more than 6,000 mentioning bat soup, which was the topic of a video that made the rounds on social media in the winter.

Let's block ads! (Why?)



COVID-19 - Latest - Google News
October 01, 2020 at 06:30AM
https://ift.tt/33mDp8Z

Study Finds ‘Single Largest Driver’ of Coronavirus Misinformation: Trump - The New York Times
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

North Carolina college student, seemingly otherwise healthy, dies of Covid-19 complications - CNN

Chad Dorrill, a 19-year-old sophomore at Appalachian State University in North Carolina, died this week after complications from Covid-19, according to the university. He was diagnosed with the virus earlier in September.
Dorrill lived off campus, and all of his classes were online. The university did not say how he contracted the virus.
"When he began feeling unwell earlier this month, his mother encouraged him to come home, quarantine, and be tested for COVID-19," Sheri Everts, chancellor of App State, said in an announcement to the university community.
"After testing positive for COVID-19 in his home county, he followed isolation procedures and was cleared by his doctor to return to Boone."
When he returned to school, Dorrill began experiencing further difficulties, Everts said. His family then picked him up, and he was hospitalized.
"Despite generally being at lower risk for severe illness, college-age adults can become seriously ill from COVID-19. As we approach the halfway mark to the last day of classes for the Fall semester, we are seeing a rise in COVID-19 cases in students," Everts warned.
Classes -- a mix of online and in-person -- began in August. Since March 27, more than 600 people at the university have contracted the virus, according to the school's tally.
Dorrill is not the first undergraduate student to die from Covid-19, but his death raises even more urgent questions around the safety of college campuses, even as universities urge safety measures amidst reopening.
CNN reached out to Dorrill's family for comment, but has not immediately received a response.
Liam Dunman, a student at App State, said the death "definitely resonated" with him.
"You don't hear about people our age dying from it at all, so it definitely got a little bit more real for me," he told CNN affiliate WSOC.
In the state of North Carolina, there have only been five reported deaths from Covid-19 in people ages 24 and under and more than 56,000 confirmed cases, according to the state's Department of Health and Human Services.

Let's block ads! (Why?)



COVID-19 - Latest - Google News
October 01, 2020 at 04:09AM
https://ift.tt/2SfHhC0

North Carolina college student, seemingly otherwise healthy, dies of Covid-19 complications - CNN
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

FDA widens US safety inquiry into AstraZeneca coronavirus vaccine - New York Post

WASHINGTON – The US Food and Drug Administration has broadened its investigation of a serious illness in AstraZeneca Plc’s COVID-19 vaccine study and will look at data from earlier trials of similar vaccines developed by the same scientists, three sources familiar with the details told Reuters.

AstraZeneca’s large, late-stage US trial has remained on hold since Sept. 6, after a study participant in Britain fell ill with what was believed to be a rare spinal inflammatory disorder called transverse myelitis.

The widened scope of the FDA probe raises the likelihood of additional delays for what has been one of the most advanced COVID-19 vaccine candidates in development. The requested data was expected to arrive this week, after which the FDA would need time to analyze it, two of the sources said.

Effective vaccines are seen as essential to help end a pandemic that has killed more than one million people worldwide.

The administration of President Donald Trump has pledged $1.2 billion to support development of the AstraZeneca vaccine and secure 300 million doses for the United States. Other leading companies in the US vaccine race include Pfizer Inc, Moderna Inc and Johnson & Johnson.

Regulators in the UK, Brazil, India and South Africa have allowed AstraZeneca to resume its clinical trials there.

The FDA, however, wants to determine whether similar side effects emerged in trials of other vaccines designed by AstraZeneca’s coronavirus vaccine partner, researchers at Oxford University, the sources said. That does not mean the agency believes there were safety issues associated with any of these vaccines, they added.

“It just shows that the FDA is being thorough,” said one of the sources.

Further complicating the situation is that the data requested by FDA is in a different format than what the US regulator requires, two of the sources said.

The FDA declined to comment on discussions involving an experimental product. Oxford did not respond to requests for comment. AstraZeneca, in a statement, said: “We are continuing to work with the FDA to facilitate review of the information needed to make a decision regarding resumption of the US trial.”

Let's block ads! (Why?)



Health - Latest - Google News
October 01, 2020 at 05:06AM
https://ift.tt/3kZHkhM

FDA widens US safety inquiry into AstraZeneca coronavirus vaccine - New York Post
Health - Latest - Google News
https://ift.tt/2zrj9Ud

Mild to severe: Immune system holds clues to virus reaction - KOMO News

[unable to retrieve full-text content]

Mild to severe: Immune system holds clues to virus reaction  KOMO News

"virus" - Google News
October 01, 2020 at 12:54AM
https://ift.tt/36luCG8

Mild to severe: Immune system holds clues to virus reaction - KOMO News
"virus" - Google News
https://ift.tt/2OagXru

The Latest: Georgia extends virus emergency rules again - The Daily Progress

[unable to retrieve full-text content]

The Latest: Georgia extends virus emergency rules again  The Daily Progress

"virus" - Google News
October 01, 2020 at 06:25AM
https://ift.tt/2ESHI2k

The Latest: Georgia extends virus emergency rules again - The Daily Progress
"virus" - Google News
https://ift.tt/2OagXru

Nebraska virus hospitalizations at high level as cases rise - KOLN

OMAHA, Neb. (AP) — The number of people hospitalized with COVID-19 remains elevated as Nebraska continues to report hundreds of new cases each day, but the number of hospitalizations is still below the peak set in the spring.

The state’s online virus tracker on Wednesday showed 215 people were hospitalized. Nebraska reported 466 new cases and six new deaths to give the state 45,044 cases and 478 deaths.

The number of people being treated in Nebraska hospitals remains below the peak of 232 set on May 27, but the number approached that when it hit 231 last Thursday. Hospitalizations were at their lowest in July when 95 people were being treated.

But the state said Wednesday that 27% of the intensive care beds and 78% of the ventilators in Nebraska remained available.

Nebraska continues to report a high rate of new cases. The seven-day rolling average of the positivity rate in Nebraska has risen over the past two weeks from 9.4% on Sept. 15 to 13.01% on Tuesday, according to an Associated Press analysis of data from Johns Hopkins University.

The seven-day rolling average of daily new cases in Nebraska has risen from 381 new cases per day on Sept. 15 to 455.71 new cases per day on Tuesday.

Copyright 2020 KOLN. All rights reserved.

Let's block ads! (Why?)



"virus" - Google News
October 01, 2020 at 01:55AM
https://ift.tt/33hlQHf

Nebraska virus hospitalizations at high level as cases rise - KOLN
"virus" - Google News
https://ift.tt/2OagXru

At virus milestone, Italian priest reflects on loss, lessons - The Associated Press

SERIATE, Italy (AP) — If there is anything the Rev. Mario Carminati and the traumatized residents of Italy’s Bergamo province remember about the worst days of the coronavirus outbreak, it’s the wail of ambulance sirens piercing the silence of lockdown.

Around the clock for weeks on end, ambulances screamed through Bergamo’s valleys and towns in a terrifying soundtrack of death, as mothers, fathers, sisters and brothers gasping for air were rushed to the hospital. Thousands never came back.

As the world counts more than 1 million COVID-19 victims, the quiet of everyday life and hum of industry has returned to Bergamo, which along with the surrounding Lombardy region was the one-time epicenter of the outbreak in Europe. But the memory of those dark winter days, and the monumental toll of dead they left behind, has remained with those who survived only to see the rest of the world fall victim, too.

ADVERTISEMENT

“They would never stop,” Carminati, the parish priest of the Bergamo town of Seriate, recalled of the ambulances. “They would drive by continuously and you would wonder ‘When will this end?’”

Bergamo recorded its first positive case Feb. 23, two days after Italy’s first locally transmitted case was detected. By the end of March, the province of Bergamo had registered a 571% increase in deaths compared with the five-year monthly average — the biggest increase in Italy and one of the biggest localized increases in mortality rate in Europe.

Many of those deaths don’t even figure into Italy’s official COVID-19 toll of 35,851, the second highest in Europe after Britain, because so many of Bergamo’s victims died at home or in nursing homes without having ever been tested. Seriate, a town of 25,000 along Bergamo’s Serio river, was particularly hard-hit, losing 200 residents. Carminate says around half were parishioners whom he knew personally.

“This is the thing that made winter more tragic then. There were no leaves on the trees, and it was all gray,” he recalled this week during one of his regular visits to the cemetery to visit with his flock. “I certainly remember it as something gray and dark, something from which you felt like you couldn’t get out: a tunnel that never ended.”

Early on in the outbreak, the first in the West, Carminati opened the doors of one of his churches, St. Joseph’s, to house the coffins that had nowhere to go because local cemeteries and crematoria were full.

At first, some 80 wooden coffins lined the central aisle of St. Joseph’s church. Carminati and a fellow priest recited the rite of the dead, with a Psalm and Scripture reading, and gave each coffin a final benediction and blessing with holy water. After a convoy of army trucks took the coffins away to be cremated, another 80 arrived. Then another.

ADVERTISEMENT

“That had a heart-breaking impact on me, something that left me with a great bitterness,” he said.

In all, Carminati says, some 260 coffins passed through his modern red-brick church in March and April, evidence of the horrific toll of the virus in Bergamo that continues today. Last month, Carminati buried his own nephew, 34-year-old Christian Persico, after he lost a five-month battle with COVID-19.

“We’ll have more because the epidemic hasn’t passed,” Carminati said ruefully during a break in his daily routine rebuilding a parish that lost its gardener, its singer at evening Mass and his friend Pio, who volunteered in the sacristy.

The idea to open his church to the coffins, when the parish was otherwise shuttered under lockdown, came naturally after hospital morgues, crematoria and cemeteries filled up. Carminati said he was asked by local authorities if his parish could house the coffins temporarily. “There was a need for space,” he said.

But Carminati also felt a need to provide the dead with a dignified farewell, since their families had been denied a funeral and final goodbye. In Italy, funerals were essentially banned during lockdown and many mourning families were themselves in quarantine or otherwise prevented from visiting isolated COVID wards.

On Palm Sunday, Carminati placed an olive frond on each coffin. Other days, he lit a candle.

Some parishioners reached out to Carminati after learning that he was taking the coffins in, wondering if he had seen their loved ones pass through. During the peak of the outbreak, some families reported chaotic, dayslong efforts to locate their dead mothers and fathers as hospitals struggling to keep people alive lost track of where the dead ended up.

Carminati would send photos of caskets when he could.

One day he fielded 10 calls from parishioners reporting deaths in the community. One call came from a nurse with word that his friend Pio had died. She dictated a final message Pio wanted Carminati to pass along to his wife.

“He had asked her to report to his wife that he had always loved her, and he still loved her very much,” Carminati said, tears welling up in his eyes. “This was his last farewell that he wanted to send his wife.”

As he watches infections and deaths surge elsewhere and the world passes the million mark, Carminati wonders why more countries didn’t pay attention to Italy’s tragedy as it was unfolding so they could be better prepared. Instead, he says, they brushed it off as typical Italian “exaggeration” and believed somehow they would be spared.

“Initially, they lost a lot of time, and then some took some absurd decisions like ‘herd immunity,’” he said. “For those of us who were in the middle of it, hearing these things at that time, we said: ‘These people are crazy. They have no idea what’s coming their way.’”

While the numbers of daily new infections and deaths in Italy today are nowhere near the peak, Carminati knows how quickly things can change. His hope looking forward is that the world learns lessons from the pandemic, both big and small.

“We need to understand we are not immortal, none of us is immortal,” he said after visiting the cemetery on a glorious, quiet autumn Sunday. “The virus ultimately returns to us this dimension of fragility.”

___

Nicole Winfield reported from Rome.

___

Follow AP’s pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak

Let's block ads! (Why?)



"virus" - Google News
September 30, 2020 at 01:43PM
https://ift.tt/33eb5oR

At virus milestone, Italian priest reflects on loss, lessons - The Associated Press
"virus" - Google News
https://ift.tt/2OagXru

At virus milestone, Italian priest reflects on loss, lessons - ABC News

Around the clock for weeks on end, ambulances screamed through Bergamo’s valleys and towns in a terrifying soundtrack of death, as mothers, fathers, sisters and brothers gasping for air were rushed to the hospital. Thousands never came back.

As the world counts more than 1 million COVID-19 victims, the quiet of everyday life and hum of industry has returned to Bergamo, which along with the surrounding Lombardy region was the one-time epicenter of the outbreak in Europe. But the memory of those dark winter days, and the monumental toll of dead they left behind, has remained with those who survived only to see the rest of the world fall victim, too.

“They would never stop,” Carminati, the parish priest of the Bergamo town of Seriate, recalled of the ambulances. “They would drive by continuously and you would wonder ‘When will this end?’”

Many of those deaths don’t even figure into Italy’s official COVID-19 toll of 35,851, the second highest in Europe after Britain, because so many of Bergamo’s victims died at home or in nursing homes without having ever been tested. Seriate, a town of 25,000 along Bergamo’s Serio river, was particularly hard-hit, losing 200 residents. Carminate says around half were parishioners whom he knew personally.

“This is the thing that made winter more tragic then. There were no leaves on the trees, and it was all gray,” he recalled this week during one of his regular visits to the cemetery to visit with his flock. “I certainly remember it as something gray and dark, something from which you felt like you couldn’t get out: a tunnel that never ended.”

Early on in the outbreak, the first in the West, Carminati opened the doors of one of his churches, St. Joseph’s, to house the coffins that had nowhere to go because local cemeteries and crematoria were full.

At first, some 80 wooden coffins lined the central aisle of St. Joseph’s church. Carminati and a fellow priest recited the rite of the dead, with a Psalm and Scripture reading, and gave each coffin a final benediction and blessing with holy water. After a convoy of army trucks took the coffins away to be cremated, another 80 arrived. Then another.

“That had a heart-breaking impact on me, something that left me with a great bitterness," he said.

In all, Carminati says, some 260 coffins passed through his modern red-brick church in March and April, evidence of the horrific toll of the virus in Bergamo that continues today. Last month, Carminati buried his own nephew, 34-year-old Christian Persico, after he lost a five-month battle with COVID-19.

“We’ll have more because the epidemic hasn’t passed,” Carminati said ruefully during a break in his daily routine rebuilding a parish that lost its gardener, its singer at evening Mass and his friend Pio, who volunteered in the sacristy.

The idea to open his church to the coffins, when the parish was otherwise shuttered under lockdown, came naturally after hospital morgues, crematoria and cemeteries filled up. Carminati said he was asked by local authorities if his parish could house the coffins temporarily. “There was a need for space,” he said.

But Carminati also felt a need to provide the dead with a dignified farewell, since their families had been denied a funeral and final goodbye. In Italy, funerals were essentially banned during lockdown and many mourning families were themselves in quarantine or otherwise prevented from visiting isolated COVID wards.

On Palm Sunday, Carminati placed an olive frond on each coffin. Other days, he lit a candle.

Some parishioners reached out to Carminati after learning that he was taking the coffins in, wondering if he had seen their loved ones pass through. During the peak of the outbreak, some families reported chaotic, dayslong efforts to locate their dead mothers and fathers as hospitals struggling to keep people alive lost track of where the dead ended up.

Carminati would send photos of caskets when he could.

One day he fielded 10 calls from parishioners reporting deaths in the community. One call came from a nurse with word that his friend Pio had died. She dictated a final message Pio wanted Carminati to pass along to his wife.

“He had asked her to report to his wife that he had always loved her, and he still loved her very much," Carminati said, tears welling up in his eyes. “This was his last farewell that he wanted to send his wife.”

As he watches infections and deaths surge elsewhere and the world passes the million mark, Carminati wonders why more countries didn’t pay attention to Italy’s tragedy as it was unfolding so they could be better prepared. Instead, he says, they brushed it off as typical Italian “exaggeration” and believed somehow they would be spared.

“Initially, they lost a lot of time, and then some took some absurd decisions like ‘herd immunity,’” he said. “For those of us who were in the middle of it, hearing these things at that time, we said: ‘These people are crazy. They have no idea what’s coming their way.’”

While the numbers of daily new infections and deaths in Italy today are nowhere near the peak, Carminati knows how quickly things can change. His hope looking forward is that the world learns lessons from the pandemic, both big and small.

“We need to understand we are not immortal, none of us is immortal,” he said after visiting the cemetery on a glorious, quiet autumn Sunday. “The virus ultimately returns to us this dimension of fragility.”

———

Nicole Winfield reported from Rome.

———

Follow AP’s pandemic coverage at https://ift.tt/2xPjH8c and https://ift.tt/2wrCaXK

Let's block ads! (Why?)



"virus" - Google News
September 30, 2020 at 01:48PM
https://ift.tt/33h9DT0

At virus milestone, Italian priest reflects on loss, lessons - ABC News
"virus" - Google News
https://ift.tt/2OagXru

Tuesday, September 29, 2020

Moderna vaccine shows signs of working in older adults - The Australian Financial Review

Moderna is already testing the higher dose in a large Phase III trial, the final stage before seeking emergency authorisation or approval.

Side effects, which included headache, fatigue, body aches, chills and injection site pain, were deemed mainly mild to moderate.

In at least two cases, however, volunteers had severe reactions.

One developed a grade three fever, which is classified as 102.2 degrees Fahrenheit (39°C) or above, after receiving the lower vaccine dose. Another developed fatigue so severe it temporarily prevented daily activities, Anderson said.

Typically, side effects occurred soon after receiving the vaccine and resolved quickly, he said.

"This is similar to what a lot of older adults are going to experience with the high dose influenza vaccine," Anderson said. "They might feel off or have a fever."

Advertisement

Norman Hulme, a 65-year-old senior multimedia developer at Emory who took the lower dose of the vaccine, said he felt compelled to take part in the trial after watching first responders in New York and Washington State fight the virus.

"I really had no side effects at all," said Hulme, who grew up in the New York area.

Hulme said he was aware Moderna's vaccine employed a new technology, and that there might be a risk in taking it, but said, "somebody had to do it".

Reuters

Let's block ads! (Why?)



Health - Latest - Google News
September 30, 2020 at 05:13AM
https://ift.tt/3cJdmfd

Moderna vaccine shows signs of working in older adults - The Australian Financial Review
Health - Latest - Google News
https://ift.tt/2zrj9Ud

Moderna COVID-19 vaccine appears safe, shows signs of working in older adults: study - Yahoo News

By Julie Steenhuysen

CHICAGO (Reuters) - Results from an early safety study of Moderna Inc's <MRNA.O> coronavirus vaccine candidate in older adults showed that it produced virus-neutralizing antibodies at levels similar to those seen in younger adults, with side effects roughly on par with high-dose flu shots, researchers said on Tuesday.

The study, published in the New England Journal of Medicine, offers a more complete picture of the vaccine's safety in older adults, a group at increased risk of severe complications from COVID-19.

The findings are reassuring because immunity tends to weaken with age, Dr. Evan Anderson, one of the study's lead researchers from Emory University in Atlanta, said in a phone interview.

The study was an extension of Moderna's Phase I safety trial, first conducted in individuals aged 18-55. It tested two doses of Moderna's vaccine - 25 micrograms and 100 micrograms - in 40 adults aged 56 to 70 and 71 and older.

Overall, the team found that in older adults who received two injections of the 100 microgram dose 28 days apart, the vaccine produced immune responses roughly in line with those seen in younger adults.

Moderna is already testing the higher dose in a large Phase III trial, the final stage before seeking emergency authorization or approval.

Side effects, which included headache, fatigue, body aches, chills and injection site pain, were deemed mainly mild to moderate.

In at least two cases, however, volunteers had severe reactions.

One developed a grade three fever, which is classified as 102.2 degrees Fahrenheit (39°C) or above, after receiving the lower vaccine dose. Another developed fatigue so severe it temporarily prevented daily activities, Anderson said.

Typically, side effects occurred soon after receiving the vaccine and resolved quickly, he said.

"This is similar to what a lot of older adults are going to experience with the high dose influenza vaccine," Anderson said. "They might feel off or have a fever."

Norman Hulme, a 65-year-old senior multimedia developer at Emory who took the lower dose of the vaccine, said he felt compelled to take part in the trial after watching first responders in New York and Washington State fight the virus.

"I really had no side effects at all," said Hulme, who grew up in the New York area.

Hulme said he was aware Moderna's vaccine employed a new technology, and that there might be a risk in taking it, but said, "somebody had to do it."

(Reporting by Julie Steenhuysen; Editing by Bill Berkrot)

Let's block ads! (Why?)



Health - Latest - Google News
September 30, 2020 at 04:04AM
https://ift.tt/33ckpKa

Moderna COVID-19 vaccine appears safe, shows signs of working in older adults: study - Yahoo News
Health - Latest - Google News
https://ift.tt/2zrj9Ud

Jim Parsons Reveals He and Husband Todd Spiewak Had Coronavirus: 'We Lost Our Sense of Smell and Taste' - PEOPLE

Jim Parsons Reveals He and Husband Todd Spiewak Had Coronavirus | PEOPLE.com

this link is to an external site that may or may not meet accessibility guidelines.

Let's block ads! (Why?)



COVID-19 - Latest - Google News
September 30, 2020 at 04:18AM
https://ift.tt/3496VhA

Jim Parsons Reveals He and Husband Todd Spiewak Had Coronavirus: 'We Lost Our Sense of Smell and Taste' - PEOPLE
COVID-19 - Latest - Google News
https://ift.tt/2VQ2gy8

Featured Post

Measles is “growing global threat,” CDC tells doctors in alert message - Ars Technica

Enlarge / A baby with measles. CDC The Centers for Disease Control and Prevention is putting clinicians on alert about the growing r...

Popular Posts